REPRODUCTIVE FUNCTION REHABILITATION IN WOMEN WITH POST-COVID MENSTRUAL DISORDERS

Summary

Objective: To evaluate the effectiveness of a personalized, multidisciplinary therapy program for restoring reproductive health in women with post-COVID menstrual cycle disorders.

Materials and Methods: A prospective randomized study included 158 women (18–45 years) who developed menstrual irregularities within 6 months after COVID-19. The intervention group (n=82) received an individualized multidisciplinary treatment (combining hormonal, metabolic and antioxidant therapy, and psychological support), while the control group (n=76) received standard symptomatic treatment. Outcomes assessed over 6 months included the return of regular menses, normalization of hormonal profiles, reduction of post-COVID symptoms, and quality of life (SF-36).

Results and discussion: Regular menstrual cycles resumed in 87.8% of women in the personalized therapy group versus 62.4% in controls (p<0.001), with a shorter average recovery time (4.2±1.8 vs 7.6±2.4 months, p<0.001). Hormonal balance was restored in 78.0% of patients vs 48.7% in the control group (p<0.001). Notably, hyperprolactinemia and subclinical hypothyroidism were corrected significantly more often under personalized treatment (p<0.001). Quality of life improved by 39% in the intervention group compared to 16% in controls (p<0.001). Adverse effects were rare, mild, and similar between groups.

Conclusions: A personalized multi-component rehabilitation strategy for post-COVID menstrual disorders demonstrated superior effectiveness over standard care, resulting in faster resumption of regular cycles, better hormonal recovery, and improved quality of life. This multidisciplinary approach can be recommended for clinical practice to rehabilitate women’s reproductive health after COVID-19.