IMPACT OF STRESS FACTORS ON THE DEVELOPMENT OF PERIODONTAL DISEASES
DOI:
https://doi.org/10.36074/grail-of-science.17.04.2026.089Keywords:
periodontal diseases, stress, psychoemotional stress, etiology of periodontitis, pathogenesis of periodontitisSummary
The article presents an analysis of national and international scientific studies examining the relationship between stress and the development of periodontal diseases. The paper highlights different pathways through which stress affects periodontal tissues, including neuroimmune mechanisms, vascular and trophic changes, behavioral factors, the neuromuscular component, as well as clinical and epidemiological evidence. An association between psychoemotional stress and the condition of periodontal tissues has been established. However, due to the multifactorial etiology of periodontal diseases, stress is not considered an independent etiological factor but rather an important modifier of disease progression. The study substantiates the relevance of a comprehensive approach to the prevention and treatment of periodontal diseases, taking into account the patient’s psychoemotional status.
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Aggarwal, K., Gupta, J., Kaur, R. K., Bansal, D., & Jain, A. (2022). Effect of anxiety and psychologic stress on periodontal health: a systematic review and meta-analysis. Quintessence International, 53(2), 144-154. https://doi.org/10.3290/j.qi.b2091191.
Bakri, I., Douglas, C. W. I., & Rawlinson, A. (2013). The effects of stress on periodontal treatment: a longitudinal investigation using clinical and biological markers. Journal of clinical periodontology, 40(10), 955-961. https://doi.org/10.1111/jcpe.12142. DOI: https://doi.org/10.1111/jcpe.12142
Bansal, J., Bansal, A., Shahi, M., Kedige, S., & Narula, R. (2014). Periodontal emotional stress syndrome: Review of basic concepts, mechanism and management. Open J Med Psychol, 3, 250-261. http://dx.doi.org/10.4236/ojmp.2014.33026. DOI: https://doi.org/10.4236/ojmp.2014.33026
Bhagat, M., Tapashetti, R., Fatima, G., & Bhutani, N. (2020). Effects of stress over periodontium. Galore International Journal of Health Sciences and Research, 5(1), 46-57.
Boitsaniuk, S., Levkiv, M., & Ostrovskyi, P. (2025). The Impact of Stress on Periodontal Health: A Biomarker-Based Review of Current Evidence. MEDICINE, 3(2).
Castro, M. M., Ferreira, R. D. O., Fagundes, N. C., Almeida, A. P., Maia, L. C., & Lima, R. R. (2020). Association between psychological stress and periodontitis: a systematic review. European journal of dentistry, 14(01), 171-179. https://doi.org/10.1055/s-0039-1693507. DOI: https://doi.org/10.1055/s-0039-1693507
Celik, D., & Kantarci, A. (2021). Vascular changes and hypoxia in periodontal
disease as a link to systemic complications. Pathogens, 10(10), 1280. https://doi.org/10.3390/pathogens10101280. DOI: https://doi.org/10.3390/pathogens10101280
Coelho, J. M. F., Miranda, S. S., da Cruz, S. S., Trindade, S. C., Passos-Soares, J. D. S., Cerqueira, E. D. M., ... & Gomes-Filho, I. S. (2020). Is there association between stress and periodontitis?. Clinical oral investigations, 24(7), 2285-2294. https://doi.org/10.1007/s00784-019-03083-9. DOI: https://doi.org/10.1007/s00784-019-03083-9
Corridore, D., Saccucci, M., Zumbo, G., Fontana, E., Lamazza, L., & Stamegna, C. (2023) Impact of stress on periodontal health: literature revision. healthcare (Basel), 11 (10): 1516. https://doi.org/10.3390/healthcare11101516. DOI: https://doi.org/10.3390/healthcare11101516
Decker, A. M., Kapila, Y. L., & Wang, H. L. (2021). The psychobiological links between chronic stress‐related diseases, periodontal/peri‐implant diseases, and wound healing. Periodontology 2000, 87(1), 94-106. https://doi.org/10.1111/prd.12381. DOI: https://doi.org/10.1111/prd.12381
Hingorjo, M. R., Owais, M., Siddiqui, S. U., Nazar, S., & Ali, Y. S. (2025). The impact of psychological stress on salivary cortisol levels in periodontitis patients: a case-control study. BMC Oral Health, 25(1), 276. https://doi.org/10.1186/s12903-024-05017-8. DOI: https://doi.org/10.1186/s12903-024-05017-8
Kononova, O., & Borysenko, A. (2021). Relationship between psycho-emotional stress and periodontal disease. European Journal of Molecular & Clinical Medicine, 8( 03). https://surl.li/saeubs.
Kopchak, O. V., Marchenko, N. S., & Yanishevska Ya, V. (2020). Modeling of chronic generalized periodontitis in laboratory animals (literature review). Медичні перспективи, 25(3), 22-29. https://doi.org/10.26641/2307-0404.2020.3.214646. DOI: https://doi.org/10.26641/2307-0404.2020.3.214646
Macrì, M., D’Albis, G., D’Albis, V., Antonacci, A., Abbinante, A., Stefanelli, R., ... & Festa, F. (2024). Periodontal health and its relationship with psychological stress: a cross-sectional study. Journal of clinical medicine, 13(10), 2942. https://doi.org/10.3390/jcm13102942. DOI: https://doi.org/10.3390/jcm13102942
Pupin, T. I., Honta, Z. M., Shylivskyy, I. V., Nemesh, O. M., & Burda, K. B. (2022). The role of adaptive-stress response in the pathogenesis of periodontal diseases. Wiadomosci lekarskie, 75(4 pt 2), 1022-1025. DOI: 10.36740/WLek20220420119. DOI: https://doi.org/10.36740/WLek20220420119
Spector, A. M., Postolache, T. T., Akram, F., Scott, A. J., Wadhawan, A., & Reynolds, M. A. (2020). Psychological Stress: A Predisposing and Exacerbating Factor in Periodontitis. way, 15, 16. https://doi.org/10.1007/s40496-020-00282-2. DOI: https://doi.org/10.1007/s40496-020-00282-2
Villafuerte, K. R. V., Palucci Vieira, L. H., Santos, K. O., Rivero-Contreras, E., Lourenço, A. G., & Motta, A. C. F. (2025). Psychological stress reduces the effectiveness of periodontal treatment: a systematic review. Journal of Clinical Medicine, 14(5), 1680. https://doi.org/10.3390/jcm14051680. DOI: https://doi.org/10.3390/jcm14051680
Villafuerte, K. R. V., Vieira, L. H. P., & Santos, K. O. (2024). Influence of psychological stress on the response to periodontal treatment: protocol for a systematic review. JMIR Research Protocols, 13(1), e56765. https://doi.org/10.2196/56765. DOI: https://doi.org/10.2196/56765
Warren, K. R., Postolache, T. T., Groer, M. E., Pinjari, O., Kelly, D. L., & Reynolds, M. A. (2014). Role of chronic stress and depression in periodontal diseases. Periodontology 2000, 64(1), 127-138. https://doi.org/10.1111/prd.12036. DOI: https://doi.org/10.1111/prd.12036
Zhang, J., Lin, S., Luo, L., Zhang, Q., Jiao, Y., & Liu, W. (2023). Psychological stress: neuroimmune roles in periodontal disease. Odontology, 111(3), 554-564. https://doi.org/10.1007/s10266-022-00768-8. DOI: https://doi.org/10.1007/s10266-022-00768-8
Zheng, D. X., Kang, X. N., Wang, Y. X., Huang, Y. N., Pang, C. F., Chen, Y. X., ... & Peng, Y. (2021). Periodontal disease and emotional disorders: A meta‐analysis. Journal of Clinical Periodontology, 48(2), 180-204. https://doi.org/10.1111/jcpe.13395. DOI: https://doi.org/10.1111/jcpe.13395
Ємельянова, Н. Ю. (2024). Роль окисного стресу у виникненні пародонтиту на тлі метаболічно-асоційованих захворювань. Український терапевтичний журнал, (3), 46-51. http://orcid.org/0000-0001-6089-6206.
Терещук, О., Василишин, У., & Гатальська , Є. (2024). Бруксизм як причина виникнення нейрофізіологічних змін у тригемінальному комплексі. Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії, 24(1), 274-279. https://doi.org/10.31718/2077-1096.24.1.274. DOI: https://doi.org/10.31718/2077-1096.24.1.274