THE DEPENDENCE OF HUMAN HEALTH AND DISEASE ON THE LEVEL OF VITAMIN D

THE DEPENDENCE OF HUMAN HEALTH AND DISEASE ON THE LEVEL OF VITAMIN D

Authors

DOI:

https://doi.org/10.36074/grail-of-science.20.02.2026.156

Keywords:

vitamin D, vitamin D deficiency, insolation, calcium-phosphorus metabolism, bone, tissue, immune system, obesity, prevention, morbidity, public health

Summary

Vitamin D is one of the key regulators of calcium and phosphorus homeostasis and plays an important role in bone tissue formation, as well as in the functioning of the immune, endocrine, and nervous systems. Under modern conditions, vitamin D deficiency has acquired a global character and is observed not only among individuals with chronic diseases but also among clinically healthy populations, particularly children and young adults. Limited insolation, lifestyle changes, dietary disorders, obesity, as well as diseases of the gastrointestinal tract contribute significantly to reduced vitamin D levels. Numerous scientific studies confirm the association between vitamin D deficiency and the development of rickets, osteoporosis, diabetes mellitus, cardiovascular, oncological, and neurodegenerative diseases, as well as an increased risk of infectious diseases, including COVID-19. Timely diagnosis and adequate prevention of vitamin D deficiency are essential components of public health preservation and reduction of disease incidence. Thus, studying the role of vitamin D and substantiating the need for its monitoring and correction remains a relevant direction of modern medicine.

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References

Kvashnina L. Vitamin D in pediatrics: myths and realities of today. https://www.vz.kiev.ua/vitamin-d-v-pediatriyi-mify-ta-realiyi-sogodennya/

Crowe FL, Jolly K, MacArthur C, et al. Trends in the incidence of testing for vitamin D deficiency in primary care in the UK: a retrospective analysis of The Health Improvement Network (THIN), 2005–2015. BMJ Open 2019; 9: e028355. doi:10.1136/ bmjopen-2018-028355/ DOI: https://doi.org/10.1136/bmjopen-2018-028355

Zhang Y, Fang F, Tang J, Jia L, Feng Y, Xu P, Faramand A. Association between vitamin D supplementation and mortality: systematic review and meta-analysis. BMJ. 2019 Aug 12; 366: l4673. doi: 10.1136/bmj. l4673. Erratum in: BMJ. 2020 Sep 22;370:m2329. PMID: 31405892; PMCID: PMC6689821. doi: 10.1136/bmj.m2329. DOI: https://doi.org/10.1136/bmj.m2329

Чжао С, Гарднер К, Тейлор В. та ін. Оцінка вітаміну D у первинній медичній допомозі: зміна моделей тестування. Лондон: J Prim Care (Абінгдон), 2015; 7:15–22. https://doi.org/10.1080/17571472.2015.11493430 DOI: https://doi.org/10.1080/17571472.2015.11493430

Пайк JW, Christakos S. Біологія та механізми дії гормону вітаміну D. Endocrinol Metab Clin North Am. 2017; 46:815–843. doi: 10.1016/j.ecl.2017.07.001 https://pmc.ncbi.nlm.nih.gov/articles/PMC5762112/ DOI: https://doi.org/10.1016/j.ecl.2017.07.001

Vinh quôc Luong K, Thi Hoàng Nguyên L. Вітамін D і хвороба Паркінсона. J Neurosci Res. 2012; 90:2227–2236. DOI: 10.1002/JNR.23115. https://onlinelibrary.wiley.com/doi/10.1002/jnr.23115 DOI: https://doi.org/10.1002/jnr.23115

Bae, J.H., Choe, H.J., Holick, M.F. et al. Association of vitamin D status with COVID-19 and its severity. Rev Endocr Metab Disord 23, 579–599 (2022). https://doi.org/10.1007/s11154-021-09705-6 DOI: https://doi.org/10.1007/s11154-021-09705-6

Michael F. Holick, Neil C. Binkley Evaluation et all. Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline Open Access, The Journal of Clinical Endocrinology & Metabolism, Volume 96, Issue 7, 1 July 2011, p. 1911–1930, https://doi.org/10.1210/jc.2011-0385/ DOI: https://doi.org/10.1210/jc.2011-0385

Author Biographies

Oksana Melnyk, Donetsk National Medical University, Ukraine

PhD, Assistant of professor at the Department of Pediatrics, Neonatology and Children`s Infections

Denis Fesenko, Donetsk National Medical University, Ukraine

Student of the Medical Faculty

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Published

23.02.2026

Number of views 35

How to Cite

Melnyk, O., & Fesenko, D. (2026). THE DEPENDENCE OF HUMAN HEALTH AND DISEASE ON THE LEVEL OF VITAMIN D. Grail of Science, (62), 1298–1301. https://doi.org/10.36074/grail-of-science.20.02.2026.156

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